P4-584: APOE GENOTYPE INFLUENCE ON HIPPOCAMPAL SUBFIELDS IN COGNITIVELY NORMAL AND ALZHEIMER DISEASE SUBJECTS
نویسندگان
چکیده
منابع مشابه
Influence of APOE Genotype on Whole-Brain Functional Networks in Cognitively Normal Elderly
This study aimed to investigate the influence of apolipoprotein E (APOE) ε4 allele on whole-brain functional networks in cognitively normal (CN) elderly by applying graph theoretical analysis to brain glucose metabolism. Eighty-six CN elderly [28 APOE ε4 carriers (ε4+) and 58 non-carriers (ε4-)] underwent clinical evaluation and resting [(18)F] fluorodeoxyglucose positron emission tomography sc...
متن کاملEffect of APOE ε4 status on intrinsic network connectivity in cognitively normal elderly subjects.
OBJECTIVE To examine default mode and salience network functional connectivity as a function of APOE ε4 status in a group of cognitively normal age-, sex-, and education-matched older adults. DESIGN Case-control study. SUBJECTS Fifty-six cognitively normal APOE ε4 carriers and 56 age-, sex- and education-matched cognitively normal APOE ε4 noncarriers. MAIN OUTCOME MEASURE Alterations in i...
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BACKGROUND AND PURPOSE The basis for decreased vulnerability to AD among apoE ε2 carriers is unknown. The purpose of this study was to use diffusion tensor imaging to detect possible differences in white matter integrity between cognitively normal elderly apoE ε2 carriers and apoE ε3/ε3 controls. MATERIALS AND METHODS Thirty-nine cognitively normal elderly individuals (19 heterozygous carrier...
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This article presents the case of a cognitively normal patient who is requesting a procedure (amyloid imaging) recently approved for the diagnosis of Alzheimer disease (AD) in patients with cognitive impairment. The predictive value of this test in unaffected people is not clearly established. Knowing the results of the test will have no effect on therapeutic options, although the patient may m...
متن کاملReduced hippocampal activity during encoding in cognitively normal adults carrying the APOE ɛ4 allele.
Apolipoprotein (APOE) ɛ4-related differences in memory performance have been detected before age 65. The hippocampus and the surrounding medial temporal lobe (MTL) structures are the first site affected by Alzheimer's disease (AD) and the MTL is the seat of episodic memory, including visuo-spatial memory. While reports of APOE ɛ4-related differences in these brain structures are not consistent ...
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ژورنال
عنوان ژورنال: Alzheimer's & Dementia
سال: 2019
ISSN: 1552-5260
DOI: 10.1016/j.jalz.2019.08.132